论文部分内容阅读
近期JAMA上发表的一项最新孟德尔随机研究表明,与一般人群相比,存在血清钙水平增高遗传倾向者发生冠状动脉疾病(CAD)及心肌梗死(MI)的风险增加。为评估与血清钙水平较高相关的遗传变异是否增加CAD及MI风险,研究者瑞典Karolinska研究所的Susanna Larson等从CAD全基因组复制与荟萃分析及CAD遗传学研究中全基因组关联荟萃分析中获取已知的钙相关单核苷酸多态性(SNPs)信息。对CAD遗传学研究中60 801例CAD患
A recent Mendelian randomized study published on JAMA showed an increased risk of coronary artery disease (CAD) and myocardial infarction (MI) in those with genetic predisposition to elevated serum calcium levels compared with the general population. To assess whether genetic variants associated with higher serum calcium levels increase CAD and MI risk, Susanna Larson et al. At the Karolinska Institute in Sweden were obtained from a genome-wide meta-analysis of CAD genome-wide duplications and meta-analyzes and CAD genetic studies Known calcium-related single nucleotide polymorphism (SNPs) information. Of 60 801 CAD cases studied in CAD genetics