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目的探讨乙型肝炎肝硬化反复发作的影响因素。方法采用病例对照研究,以在郑州市第六人民医院住院两次以上的乙型肝炎肝硬化患者为病例组。同期住院的首次发病的乙型肝炎肝硬化患者为对照组。采用问卷方式了解一般情况,定量分析两组患者肝组织病理检查及免疫组化检查结果。结果多因素非条件Logis-tic回归分析得出:CHB病史、父、母患有乙型肝炎史、手术史、饮酒史、甜食摄入、重叠HEV病毒感染、白细胞低、胆碱酯酶低下、胆固醇低、胃底静脉曲张、高PCR-HBVDNA定量、肝脏组织炎症程度高和肝脏组织免疫组化HBcAg表达是影响乙型肝炎肝硬化反复发作的因素重要危险因素。结论从事体力劳动、慢性乙型肝炎病史、父、母患有乙型肝炎、手术史、饮酒史、吸烟史,甜食摄入、重叠HEV病毒感染、肝脏组织炎症程度高、肝脏组织HBeAg表达、PCR-HBVDNA定量高、血清球蛋白高、血清前白蛋白低、白细胞低、胆碱酯酶低下、凝血酶原活动度低是乙型肝炎肝硬化反复发作的影响因素。使用抗病毒药物是保护性因素。
Objective To investigate the influencing factors of recurrent hepatitis B cirrhosis. Methods A case-control study was conducted in case of hepatitis B cirrhosis patients who were hospitalized more than twice in Zhengzhou Sixth People’s Hospital. The first incidence of hospitalized patients with hepatitis B cirrhosis during the same period was the control group. Using the questionnaire to understand the general situation, quantitative analysis of two groups of patients with liver histopathology and immunohistochemistry results. Results The multivariate Logis-tic regression analysis showed that the history of CHB, history of hepatitis B, history of surgery, history of alcohol intake, confectionery intake, overlapping HEV virus infection, low leukopenia, low cholinesterase, Low cholesterol, gastric varices, high quantitative PCR-HBVDNA, high degree of inflammation in liver tissue and immunohistochemical expression of HBcAg in liver tissue are important risk factors of recurrent hepatitis B cirrhosis. Conclusions Engaged in physical labor, history of chronic hepatitis B, hepatitis B, operation history, alcohol consumption history, smoking history, confectionery intake, overlap HEV virus infection, high degree of inflammation in liver tissue, HBeAg expression in liver tissue, PCR High quantitative HBV DNA, high serum globulin, low serum prealbumin, low leukocytes, low cholinesterase, low activity of prothrombin is a recurrence of hepatitis B cirrhosis factors. The use of antiviral drugs is a protective factor.