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目的探讨丹参多酚酸盐对慢性阻塞性肺疾病急性加重期(AECOPD)患者血小板及凝血功能的影响。方法 80例AECOPD患者随机分为治疗组和对照组,每组各40例。对照组采取常规治疗,治疗组在此基础上静脉滴注丹参多酚酸盐(一日0.2 g),连续治疗2周。观察治疗前后两组患者血浆P-选择素、D-二聚体、纤维蛋白原水平以及血小板凝集率变化情况。结果治疗后,两组P-选择素、D-二聚体、纤维蛋白原水平以及血小板凝集率等指标均有下降(P<0.05或P<0.01),且治疗组各指标下降更为显著,组间差异有统计学意义(P<0.05或P<0.01)。结论丹参多酚酸盐可抑制血小板凝集,调节凝血功能紊乱,预防AECOPD患者血栓形成作用值得研究。
Objective To investigate the effects of salvianolate on platelets and coagulation in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods 80 patients with AECOPD were randomly divided into treatment group and control group, 40 cases in each group. Control group to take conventional treatment, the treatment group on the basis of intravenous salvianolate (0.2 g day), continuous treatment for 2 weeks. Changes of plasma P-selectin, D-dimer, fibrinogen and platelet aggregation were observed before and after treatment. Results After treatment, the levels of P-selectin, D-dimer, fibrinogen and platelet aggregation rate decreased (P <0.05 or P <0.01), and the indexes in treatment group decreased more significantly There was significant difference between groups (P <0.05 or P <0.01). Conclusion Salvianolic acid polyphenols can inhibit platelet aggregation, coagulation disorders, prevention of thrombosis in patients with AECOPD is worth studying.