目的：探讨胰岛素样生长因子１（ＩＧＦ１） 的免疫调节作用。方法：随机抽取健康个体８２ 名和肿瘤个体１２６ 名，体外提取外周血淋巴细胞后将ＩＬ２ 和或ＩＧＦ１ 共同培养，用３ ＨＴｄＲ 掺入法、３ ＨＴｄＲ 释放法及流式细胞仪检测淋巴细胞增殖活性、杀伤活性和ＣＤ４＋ ＣＤ８＋ 比率。结果：适当浓度的ＩＧＦ１（５０ ｎｇｍｌ）在体外能协同ＩＬ２ 促进ＬＡＫ细胞的增殖，增强其杀伤Ｒａｊｉ细胞的活性，提高淋巴细胞亚群ＣＤ４＋ ＣＤ８＋ 的比率。结论：ＩＧＦ１ 在体外对人体外周血免疫细胞起正向调节作用。 Objective: To investigate the immunoregulatory effects of insulin-like growth factor 1 (IGF-1). METHODS: A total of 82 healthy individuals and 126 tumors were randomly selected. After peripheral blood lymphocytes were extracted in vitro, IL-2 and IGF-1 were co-cultured with 3 H-TdR incorporation, 3 H-TdR release and flow. Cytometric examination of lymphocyte proliferation activity, killing activity and CD4+ CD8+ ratio. Results: The appropriate concentration of IGF 1 (50 ngml) could synergistically promote the proliferation of LAK cells in vitro, increase the activity of killing Raji cells, and increase the ratio of CD4+ CD8+ lymphocyte subsets. Conclusion: IGF1 plays a positive regulatory role in human peripheral blood immune cells in vitro.