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扑热息痛具弱酸性,是广泛应用的解热镇痛药。为了研究单剂量、多剂量的西米替丁对扑热息痛药代动力学的影响,作者在4名正常志愿者身上进行了随机交叉试验。每个受试者都进行三项试验:单独服用一次量750mg扑热息痛(A);该剂量扑热息痛和200
Paracetamol is weakly acidic and is a widely used antipyretic and analgesic. In order to investigate the effect of single dose, multiple doses of cimetidine on the pharmacokinetics of paracetamol, the authors conducted a randomized crossover study in four normal volunteers. Three trials were performed for each subject: 750 mg paracetamol (A) alone once a single dose; paracetamol and 200