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目的 研究32 例子宫平滑肌肉瘤的诊治及预后因素。 方法 1962 年7 月~1994 年10 月,收治32例子宫平滑肌肉瘤,其中Ⅰ期11 例,Ⅱ期4 例,Ⅲ期14 例,Ⅳ期3 例,32 例均行手术治疗,术后补充化疗16 例,补充放疗8 例,补充化疗加放疗7 例。 结果 本组病例总的二年及五年生存率分别为552% 及365 % 。Ⅰ~Ⅱ期的二年及五年生存率为733% 及643 % ,Ⅲ~Ⅳ期的二年及五年生存率为357 % 及0 % 。 结论 子宫平滑肌肉瘤预后和临床分期、治疗方法、子宫大小、绝经因素等有明显关系,术后辅以化疗和放疗有可能提高生存率。
Objective To study the diagnosis and treatment of 32 cases of uterine leiomyosarcoma and its prognostic factors. Methods From July 1962 to October 1994, 32 cases of uterine leiomyosarcoma were treated, including 11 cases of stage Ⅰ, 4 cases of stage Ⅱ, 14 cases of stage Ⅲ, 3 cases of stage Ⅳ, 32 cases underwent surgery and postoperative chemotherapy 16 cases, 8 cases of supplementary radiotherapy, plus chemotherapy plus radiotherapy in 7 cases. Results The overall two-year and five-year survival rates were 552% and 365% in this group. The two-year and five-year survival rates of stage Ⅰ-Ⅱ were 733% and 643% respectively. The two-year and five-year survival rates of stage Ⅲ-Ⅳ were 357% and 0% respectively. Conclusion The prognosis of uterine leiomyosarcoma and clinical stage, treatment, uterine size, menopausal factors have a clear relationship, postoperative adjuvant chemotherapy and radiotherapy may improve the survival rate.