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目的 :探讨肝纤维化血清标志物与肝活检病理变化之间的关系。方法 :对 82例慢性肝炎肝活检组织作HE染色及网状纤维嗜银染色 ,分别判断慢性肝炎炎症活动度及纤维化程度 ,同时检测患者血清HA、LN、Ⅳ .C、PCⅢ含量。结果 :血清HA、LN、PCⅢ含量均与慢性肝炎炎症活动度和纤维化程度呈正相关。LN、PCⅢ在肝纤维化早期即开始明显增高 ;HA从S2 期开始升高 ,但升高的幅度较大 ;Ⅳ .C在S3期才开始明显升高。HA、LN、PCⅢ在炎症早期即有升高 ;Ⅳ .C在G1-G3级都不升高 ,G4 级才有明显增高。结论 :检测慢性肝炎患者血清HA、LN、Ⅳ .C、PCⅢ含量可用于判断其病情严重程度 ,LN、PCⅢ能较早反映肝纤维化程度。
Objective: To investigate the relationship between serum markers of liver fibrosis and pathological changes of liver biopsy. Methods: 82 cases of chronic hepatitis liver biopsy tissue were stained with hematoxylin and eosin for the determination of inflammatory degree and degree of fibrosis in patients with chronic hepatitis, meanwhile serum HA, LN, Ⅳ .C and PCⅢ levels were detected. Results: Serum levels of HA, LN and PCⅢ were positively correlated with the degree of inflammation and fibrosis in chronic hepatitis. LN and PC Ⅲ began to increase significantly in the early stage of liver fibrosis; HA increased from S2 stage, but increased significantly; Ⅳ. C began to increase significantly in S3 stage. HA, LN, PC Ⅲ increased in the early stage of inflammation; Ⅳ .C in the G1-G3 grade did not increase, G4 grade was significantly higher. Conclusion: The detection of serum HA, LN, Ⅳ .C and PCⅢ levels in patients with chronic hepatitis can be used to determine the severity of the disease. LN and PC Ⅲ can reflect the degree of liver fibrosis earlier.