论文部分内容阅读
目的观察Survivin、CD44蛋白表达与乳腺癌患者预后生存期的关系。方法选取我院2008年1月-2010年12月期间收治的乳腺癌并行根治术患者60例(乳腺癌组),采用免疫组织化学法检测送检乳腺癌标本中Survivin、CD44表达水平,并按组织病理学检查阴、阳性结果将入选患者分为双阳性组、单阳性组及双阴性组,对不同分组患者进行术后随访,分析乳腺癌患者Survivin、CD44表达水平与其术后生存期的关系;并选取同期送检并经组织病理学检查确诊为正常的乳腺组织标本20例(对照组)进行对比。结果乳腺癌组乳腺标本中Survivin、CD44表达均明显高于对照组(P<0.05);经随访双阴性组患者5年生存率及平均生存期最高,单阳性组患者次之,双阳性患者5年生存率最低。结论 Survivin、CD44在乳腺癌组织中表达均为阳性患者5年生存率较低,Survivin、CD44表达可做为乳腺癌患者治疗及预测预后的指标。
Objective To investigate the relationship between the expression of Survivin and CD44 and the prognosis of patients with breast cancer. Methods Sixty patients (breast cancer group) with radical mastectomy of breast cancer who were treated in our hospital from January 2008 to December 2010 were selected. The expression of Survivin and CD44 in breast cancer samples was detected by immunohistochemistry Histopathological examination of negative and positive results The selected patients were divided into double positive group, single positive group and double negative group. The patients in different groups were followed up. The relationship between the expression of Survivin and CD44 in breast cancer patients and their postoperative survival was analyzed ; And selected the same period sentinel examination and histopathological examination confirmed the normal breast tissue specimens 20 cases (control group) were compared. Results The expression of Survivin and CD44 in the breast cancer group was significantly higher than that in the control group (P <0.05). The follow-up double-negative group had the highest 5-year survival rate and the highest mean survival time. In the single positive group, The lowest annual survival rate. Conclusions The 5-year survival rates of Survivin and CD44 in patients with positive breast cancer are low. The expression of Survivin and CD44 can be used as indicators for treatment and prognosis of patients with breast cancer.