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目的:探讨新辅助静脉化疗联合宫颈癌根治术治疗后患者CD44V3和VEGF-C的表达水平。方法:选取2011年3月~2014年1月在该院择期行宫颈癌根治术的患者83例,术前采用新辅助静脉化疗的患者43例作为观察组,未采用辅助治疗的患者40例作为对照组,所有患者术中采集宫颈癌组织标本,采用免疫组化法检测CD44V3和VEGF-C表达水平。结果:观察组治疗有效率明显高于对照组,淋巴结阳性率、癌旁累及阳性率、宫颈癌组织CD44V3和VEGF-C阳性表达率均明显低于对照组,两组比较,差异均有统计学意义(P均<0.05)。CD44V3和VEGF-C表达与淋巴结转移、组织分化程度密切相关,其中有淋巴结转移、组织分化程度较低者阳性表达率明显增高,差异有统计学意义(P<0.05);经Pearson相关性分析发现,CD44V3与VEGF-C表达呈正相关(r=5.21,P<0.05)。结论:宫颈癌组织CD44V3和VEGF-C表达具有协同作用,联合检测其表达水平在评估新辅助静脉化疗治疗效果中具有重要的意义。
Objective: To investigate the expression of CD44V3 and VEGF-C after neoadjuvant venous chemotherapy combined with radical resection of cervical cancer. Methods: From March 2011 to January 2014, 83 patients undergoing elective cervical cancer radical resection in our hospital were enrolled. Forty-three patients undergoing neoadjuvant intravenous chemotherapy were selected as observation group and 40 patients without adjuvant therapy In the control group, all the patients were collected cervical cancer tissue during operation, and the expression of CD44V3 and VEGF-C were detected by immunohistochemistry. Results: The effective rate of observation group was significantly higher than that of the control group. The positive rates of lymph node, adjacent non-cancerous tissues and positive rates of CD44V3 and VEGF-C in cervical cancer tissues were significantly lower than those in control group. There were statistically significant differences between the two groups Significance (P <0.05). The expression of CD44V3 and VEGF-C were closely related to the degree of lymph node metastasis and the degree of tissue differentiation. The positive rate of lymph node metastasis and tissue differentiation was significantly higher (P <0.05). The Pearson correlation analysis showed that the expression of CD44V3 and VEGF- There was a positive correlation between the expression of CD44V3 and VEGF-C (r = 5.21, P <0.05). Conclusion: The expression of CD44V3 and VEGF-C in cervical cancer has a synergistic effect. The combined detection of the expression of CD44V3 and VEGF-C is of great significance in evaluating the therapeutic effect of neoadjuvant intravenous chemotherapy.