综述了近年来利用配体 -受体的特异性结合 ,以蛋白质及多肽作为药物载体 ,将药物定向转运到特定靶组织方面研究的进展。介绍了常用的受体及相应的药物载体 ,载体定向转运药物的机理及常用的三种药物与载体的连接方式 ,即酸敏感性共价键 ,疏水键及离子键 ,并对一些影响载体定向转运药物效率的因素进行了探讨 In this paper, the recent progress in ligand-receptor specific binding, protein and peptide as drug carriers, and targeted drug delivery to specific target tissues is reviewed. The commonly used receptors and their corresponding drug carriers, the mechanism of drug delivery by targeted drug delivery, and the connection of the three commonly used drugs to carriers, such as acid-sensitive covalent bond, hydrophobic bond and ionic bond, are introduced. The factors that influence the efficiency of drug delivery were discussed