目的 :观察孕酮和孕烯醇酮硫酸盐对东莨菪碱引起的小鼠记忆损伤的保护作用。方法 :用东莨菪碱造成小鼠记忆损伤的模型 ,应用被动避暗试验测定潜伏期以评价记忆成绩。结果 :小鼠给予东莨菪碱 (1mg·kg-1,ip)后 ,其潜伏期显著减少 ,表明造成了明显的记忆损伤。孕酮 (1,10mg·kg-1,sc)和孕烯醇酮硫酸盐 (1mg·kg-1,sc)均可以在被动避暗试验中减轻东莨菪碱引起的记忆损伤。结论 :孕酮和孕烯醇酮硫酸盐可改善记忆损伤。 Objective: To observe the protective effects of progesterone and pregnenolone sulfate against scopolamine-induced memory impairment in mice. Methods: The model of memory impairment caused by scopolamine in mice was established. Passive darkness test was used to measure the latency to evaluate memory performance. Results: The mouse scopolamine (1 mg · kg-1, ip), the latency was significantly reduced, indicating that caused a significant memory impairment. Progesterone (1, 10 mg · kg-1, sc) and pregnenolone sulfate (1 mg · kg-1, sc) all reduced scopolamine-induced memory impairment in the passive avoidance test. Conclusion: Progesterone and pregnenolone sulfate can improve memory impairment.