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目的 研究补钙对妊高征的预防作用。方法 对 88例有妊高征倾向的孕妇 (随机分为 3组 )自妊娠 2 0～ 2 4周起采用口服不同剂量的钙尔奇 - D(6 0 0 mg、12 0 0 mg)及对照的前瞻性研究 ,用荧光分光光度计测定口服钙前后的血小板游离钙离子浓度 ,并观察妊高征的发生率。结果 经补钙 6 0 0 mg后妊高征发生率 (17.2 4 % )较对照组降低 ,补钙 12 0 0 mg后 ,其妊高征发生率 (6 .90 % )明显低于对照组(2 6 .6 7% ) (P <0 .0 5) ;补钙两组血小板游离钙离子浓度与对照组相比明显降低 (P <0 .0 5)。结论 补充一定量的钙剂可降低血小板游离钙离子浓度 ,对有妊高征倾向的高危孕妇可预防妊高征的发生。
Objective To study the preventive effect of calcium supplementation on pregnancy-induced hypertension. Methods Eighty pregnant women with PIH were randomly divided into three groups. Oral administration of different dosages of Calcium - D (600 mg, 120 mg) and control Prospective study, before and after oral calcium determination of platelet free calcium concentration by fluorescence spectrophotometer and observe the incidence of PIH. Results The incidence of PIH after calcium supplementation of 600 mg (17.24%) was lower than that of the control group. The incidence of pregnancy-induced hypertension (6.90%) after calcium supplementation was significantly lower than that of the control group 26.7%) (P <0.05). The concentration of platelet calcium in the two groups of calcium supplementation was significantly lower than that in the control group (P <0.05). Conclusion Supplementation of a certain amount of calcium can reduce the platelet free calcium concentration, pregnancy-induced hypertension in high-risk pregnant women can prevent the occurrence of pregnancy-induced hypertension.