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目的评价雷贝拉唑治疗胃食管反流病的疗效。方法将2007年3月至2009年9月在江苏省灌南县中医院消化内科门诊就诊的并经胃镜检查的胃食管反流病患者290例随机分为两组,口服雷贝拉唑148例(观察组),口服奥美拉唑和多潘立酮142例(对照组)。疗程均为4周。观察两组患者临床症状烧心,反流等改善程度,复查胃镜观察糜烂的食管黏膜修复情况。结果两组治疗前后烧心,反流等症状评分下降差异有统计学意义(P<0.01),说明两组方法治疗GERD均有明显疗效。两组疗效比较差异无统计学意义。结论小剂量雷贝拉唑治疗GERD疗效肯定,与奥美拉唑和多潘立酮联合用药效果相近,而且用药不良反应少,可作为治疗GERD的首选用药。
Objective To evaluate the efficacy of rabeprazole in the treatment of gastroesophageal reflux disease. Methods From March 2007 to September 2009, 290 patients with gastroesophageal reflux disease undergoing gastroscopic examination in the Gastroenterology Outpatient Department of Guannan Chinese Medicine Hospital, Jiangsu Province were randomly divided into two groups. 148 cases were oral rabeprazole (Observation group), oral omeprazole and domperidone 142 cases (control group). The course of treatment is 4 weeks. To observe the clinical symptoms of two groups of heartburn, reflux and other improvements, review of endoscopy erosion erosion esophageal mucosa repair. Results Before and after treatment, the scores of heartburn, reflux and other symptoms decreased significantly (P <0.01), indicating that both groups have obvious curative effect in treating GERD. There was no significant difference between the two groups in curative effect. Conclusion Small dose of rabeprazole treatment of GERD positive effect, and omeprazole and domperidone combined with similar results, and less adverse drug reactions, can be used as the treatment of GERD drug of choice.