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目的:探讨高胆红素血症新生儿的阴离子间隙(anion gap,AG)变化,为治疗提供依据。方法:测定355例高胆新生儿的血清电解质、肾功能、肝功能,计算AG值,76例患儿同时做动脉血气分析。结果:高AG 145例(40.8%),正常AG 181例(51.0%),低AG 29例(8.2%)。AG增高与血Na+、BUN、Scr浓度成正比,与HCO3-、Cl-呈反比。轻、重度高胆新生儿的AG水平、高AG发生率、血电解质及肾功能比较均无显著性差异。结论:高胆红素血症新生儿高AG代谢性酸中毒发生率高,应常规测定血电解质、肾功能及动脉血气,计算AG值以指导治疗,以免盲目用碱纠酸。
Objective: To investigate the changes of anion gap (AG) in newborns with hyperbilirubinemia and provide basis for treatment. Methods: Serum electrolytes, renal function and liver function were measured in 355 cases with hyperbilirubinemia. The AG values were calculated and 76 cases were also analyzed by arterial blood gas analysis. Results: There were 145 patients (40.8%) with high AG, 181 patients (51.0%) with normal AG and 29 patients (8.2%) with low AG. AG increased with blood Na +, BUN, Scr concentration is proportional to HCO3-, Cl- was inversely proportional. There was no significant difference in AG level, high AG rate, blood electrolyte and renal function between mild and severe hyperbilirubinemia. Conclusion: Hyperbilirubinemia neonates with high incidence of high metabolic acidosis, should be routine determination of blood electrolytes, renal function and arterial blood gas, calculated AG value to guide the treatment, so as not to use blind acid correction.