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目的研究冬凌草甲素自微乳对H22移植性肿瘤模型小鼠的肿瘤抑制作用。方法采用昆明小鼠接种肝癌H22瘤株造成相应的移植性荷瘤小鼠模型,以实体瘤模型小鼠的瘤重、抑瘤率观察冬凌草甲素自微乳对小鼠移植性肿瘤H22的抑制作用;以胸腺指数、脾脏指数为指标观察冬凌草甲素自微乳对免疫器官的影响;以小鼠平均生存时间观察冬凌草甲素自微乳对腹水瘤模型小鼠的生命延长作用。结果冬凌草甲素自微乳能有效地抑制实体瘤模型荷瘤小鼠体内肿瘤的生长,低、中、高(67,100,150 mg.kg-1)3个剂量组的抑瘤率分别为:43.94%、54.65%、59.57%;冬凌草甲素自微乳给药组小鼠胸腺指数和脾脏指数与荷瘤对照组相比,无显著性差异;中剂量(100 mg.kg-1)冬凌草甲素自微乳对腹水瘤肿瘤模型小鼠的生存时间具有延长作用,与荷瘤对照组相比具显著性差异。结论冬凌草甲素自微乳对荷瘤小鼠肿瘤生长具有一定的抑制作用,抑制作用强于冬凌草甲素,并有剂量依赖性。
Objective To study the tumor suppressive effect of oridonin self-microemulsion on H22 transplanted tumor model mice. Methods A mouse model of transplanted tumor was established by inoculating hepatoma H22 tumor strain with Kunming mice. The tumor weight and tumor inhibition rate of solid tumor model mice were observed. Oridonin self-microemulsion versus mouse transplant tumor H22 Inhibitory effect; thymus index, spleen index as indicators to observe the effect of oridonin self-microemulsion on immune organs; the average survival time of mice to observe the oridonin self-microemulsion on the life of ascites tumor model mice Extend the effect. Results Oridonin self-microemulsion could effectively inhibit the growth of tumor in tumor-bearing mice. The tumor inhibition rates of low, medium and high (67, 100, 150 mg.kg-1) groups were: 43.94. %, 54.65%, 59.57%; There was no significant difference in the thymus index and spleen index between the oridonin-administered microemulsion group and the tumor-bearing control group; medium dose (100 mg.kg-1) in winter Orthoprene self-microemulsion has a prolonged effect on the survival time of ascites tumor tumor model mice, and has a significant difference compared with the tumor-bearing control group. Conclusion Oridonin self-microemulsion has a certain inhibitory effect on the tumor growth of tumor-bearing mice, and its inhibitory effect is stronger than that of oridonin. It is dose-dependent.