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目的研究系统性红斑狼疮(SLE)患者外周血CD16的变化,并与病情活动性及脏器损害等临床资料进行相关性分析,探讨CD16在SLE发病中的作用。方法选择35例SLE患者,根据SLEDAI评分及有无蛋白尿、肾功能损害等进行分组;同时选择35例健康者为对照组,采用流式细胞术检测外周血中CD16的水平。结果 SLE患者外周血CD16的水平低于健康对照组,差异有统计学意义(P<0.05);活动组SLE患者外周血中CD16阳性细胞较非活动组降低不明显(P>0.05);狼疮性肾炎(LN)组较非LN组的外周血CD16阳性细胞下降明显(P<0.05),且LN组中已出现肾功能损害者CD16阳性细胞明显低于尚未出现肾功能损害组(P<0.05)。结论 CD16可能参与SLE的发病过程,且与其肾脏病变程度相关。
Objective To study the changes of CD16 in peripheral blood of patients with systemic lupus erythematosus (SLE), and to analyze the correlation between the activity of CD16 and the clinical data of organ damage, and to explore the role of CD16 in the pathogenesis of SLE. Methods Thirty-five patients with SLE were divided into three groups according to SLEDAI score, proteinuria and renal dysfunction. 35 healthy subjects were selected as control group. The level of CD16 in peripheral blood was detected by flow cytometry. Results The level of CD16 in the peripheral blood of patients with SLE was lower than that of healthy controls (P <0.05). The number of CD16 positive cells in peripheral blood of SLE patients was not significantly lower than that of inactive patients (P> 0.05) The number of CD16 positive cells in LN group was significantly lower than that in non-LN group (P <0.05), and the number of CD16 positive cells in LN group was significantly lower than that in non-LN group (P <0.05) . Conclusion CD16 may be involved in the pathogenesis of SLE and is related to the degree of renal disease.