Antihaemolytic and snake venom neutralizing effect of some Indian medicinal plants

来源 :亚太热带医药杂志(英文版) | 被引量 : 0次 | 上传用户:xingdeyanglina
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective:To validate traditional claims of usefulness of the Indian plants in management of poisonous snakebite and evaluate the antivenom properties displayed by the alcoholic extracts ofAndrographis paniculata (A. paniculata),Crateva magna (C. magna),Gloriosa superba (G. superba) andHydrocotyle javanica (H. javanica).Methods:These plants were collected, identified and the extracts were prepared by using conventional Soxhlet ethanol extraction technique. The venom neutralization activity was accessed in mice (20-25g) and number of mortalities was observed against clinically important snake (Naja nigricollis) venom. Present study also deals with in vitro membrane stabilizing activity of these plants against hyposaline induced human red blood corpuscles(HRBC).Results: Extracts ofH. javanica andG. superba gave80 % and90 %protection to mice treated with minimum lethal dose of venom (LD99). These two plants showed significant neutralization effect against the venoms of Naja nigricollis venom.H. javanica andG. superba(25-100 mg/mL) produced significant changes of membrane stabilization of human red blood cells(HRBC)exposed to hyposaline-induced haemolysis.Conclusions:We conclude that probably due to presence of various phytochemicals plays an important role in the anti-venom potential of these Indian medicinal plants against Naja nigricollis venom. The above observations confirmed thatA. paniculata, C. magna, G. superba andH. javanica plant extracts possess potent snake venom neutralizing capacity and could potentially be used as an adjuvants for antivenin therapy in case of snakebite envenomation, especially against the local effects of cobra venoms.
其他文献
原发性腹膜后脂肪肉瘤是一种罕见的低度恶性肿瘤,约占成年人恶性肿瘤的1%。根治性切除是原发性腹膜后脂肪肉瘤最重要的治疗手段,放疗可以降低肿瘤局部复发率,图像引导的调强放射治疗(IG-IMRT)等新技术的应用降低了不良反应发生率,近年发现的一系列新型化疗药物及分子靶向药物也显示出了良好的治疗前景。目前,原发性腹膜后脂肪肉瘤需根据疾病的病理学分型和肿瘤特点等因素,采取包括手术、放疗、化疗以及分子靶向治疗
为探讨非胰岛素依赖型糖尿病(NIDDM)患者血清性激素变化与胰岛素、脂质及大血管病变的关系,检测了60例50岁以上NIDDM(包括27例伴大血管病变)患者血清雌二醇(E 2 )、睾酮(T)水
A 27 year-old lady, presented with sudden loss of vision in the right eye for a week. It was followed by poor vision in the left eye after 3 days. It involved t
通过佛教僧人在当地的特殊地位,通过动员僧人,建立组织网络,制定工作计划,培训僧侣/宗教干部及管理人员,收集、整理相关资料并翻译成傣文宣传材料,到泰国学习“取经”等措施,
目的建立住院患者用药医嘱前置审核系统,提高住院患者用药医嘱审核率。方法用药医嘱前置审核系统采用浏览器/服务器(B/S)与客户/服务器(C/S)混合架构,编程采用JAVA语言,与医院信息系统及数据集成平台相连,在首都医科大学宣武医院成功运行的处方前置审核系统的基础上改进了审核模块,在处方合理用药审核智库中新增相关规则2万余条,实现了适应证、用法用量、给药途径的严重错误拦截,中成药适应证的适配性转译,
Objective:To identify a full length cDNA sequence of a novel tetraspanin(TSP) homologue from Spirometra erinaceieuropaeiand to predict the structure and functio
目的 探究使用孟鲁司特纳联合芩暴红止咳合剂治疗临床上小儿咳嗽变异性哮喘的方法、疗效以及安全性问题.方法 选取2018年5-8月5个月期间在重庆市彭水县人民医院儿科门诊或急
1例50岁女性乙型肝炎肝硬化患者于8年前开始口服拉米夫定(100 mg/d)治疗。用药1年后出现拉米夫定耐药,加用阿德福韦酯10 mg/d。联合抗病毒治疗约6年后,患者出现下肢无力且症状逐渐加重,1年内相继出现右侧季肋区疼痛伴翻身困难、下肢活动受限和左侧季肋区疼痛。实验室检查示血磷0.55 mmol/L,血钙2.13 mmol/L,血尿酸98 μmol/L,考虑为范可尼综合征(FS),停用阿德福韦
目的:分析金黄散在急性痛风性关节炎中的应用效果和护理要点.方法:选取2017年5月-2018年5月50例医院收治的急性痛风性关节炎患者,并将本次研究入选患者随机分为观察组与对照
高龄血管病患者多合并有高血压、冠心病、糖尿病等.手术麻醉风险大.本文总结了20例高龄血管病患者行血管手术的麻醉体会.