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鼠双微粒体2(MDM2)基因最初是从一个含有双微粒体(DM)的自发转化的BALB/3T3DM细胞中克隆出来的一个高度扩增的癌基因,编码的蛋白可以和抑癌基因蛋白p53相互作用。MDM2在多种肿瘤细胞中高表达,在肝癌细胞HepG2
The murine double-microsome 2 (MDM2) gene was originally a highly amplified oncogene cloned from a spontaneously transformed BALB/3T3DM cell containing double microsomes (DM), encoding the protein and the tumor suppressor protein p53. interaction. MDM2 is highly expressed in a variety of tumor cells, in hepatoma cells HepG2