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多系统萎缩症(multiple system atrophy,MSA)由 Graham 及 Oppenheimer 提出,也称进行性系统变性,包括橄榄桥脑小脑萎缩(olivopontocerebellar atrophy,OPCA)、纹状体黑质变性(striato-nigral degeneration,SND)以及 Shy-Drager 综合征(SDS)。由于这些疾病在病理上不同时期有不同程度的小脑系统、锥体外系统、植物神经系统等多系统的变性及萎缩,故称其为 MSA。依其主要病变的部位称为 OPCA,SND,SDS,而实际上为同一病理过程。本文将介绍 OPCA,SND,SDS 的临床主要表现;分析其共同症状:小脑症状、锥体外系症状,植物神经症状硬其病情的演变过程。MSA 的主要临床表现OPCA 本病的病理改变以小脑桥脑橄榄核为主,也有基底核的黑质、纹状体、脊髓侧
Multiple system atrophy (MSA) was proposed by Graham and Oppenheimer, also known as progressive systemic degeneration, including olivopontocerebellar atrophy (OPCA), striato-nigral degeneration (SND ) And Shy-Drager syndrome (SDS). Because of these diseases in different stages of the pathological different degrees of cerebellar system, extrapyramidal system, autonomic nervous system and other multi-system degeneration and atrophy, it is called MSA. According to the main lesion site called OPCA, SND, SDS, but in fact the same pathological process. This article will introduce the main clinical manifestations of OPCA, SND, SDS; analysis of their common symptoms: cerebellar symptoms, extrapyramidal symptoms, autonomic symptoms of hard the evolution of the disease. The main clinical manifestations of MSA OPCA The pathological changes of this disease to the psoragan olive root-based, but also the basal ganglia, substantia nigra, striatum