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多发性骨髓瘤(multip le myeloma,MM)是以骨髓中克隆性浆细胞恶性增殖和异常积聚为特征的肿瘤,尤其多见于老年人,我科对2008年2月至2011年12月收治的20例MM应用沙利度胺联合VAD方案化疗进行治疗,报告如下。1资料与方法1.1临床资料20例MM均符合MM的诊断标准[1],其中男17例,女3例;年龄50～72岁,中位年龄58岁;Ⅲa期15例,Ⅲb期5例;LgA型8例,LgG11例,LgD型1例,轻链型3例;初治16例,复发或难治4例。病程3～46个月;骨髓中各期浆细胞占19%～54%;M蛋白定量32.5～88.0g/L。
Multiple myeloma (MM) is characterized by malignant proliferation and abnormal accumulation of clonal plasma cells in the bone marrow, especially in the elderly, our department from February 2008 to December 2011 were treated 20 Example MM thalidomide combined with VAD regimen chemotherapy, the report is as follows. 1 Materials and Methods 1.1 Clinical data 20 MM met the diagnostic criteria of MM [1], including 17 males and 3 females; aged 50 to 72 years, the median age of 58 years; Ⅲ a period of 15 cases, Ⅲ b 5 cases ; 8 cases of LgA type, 11 cases of LgG, 1 case of LgD type, 3 cases of light chain type; 16 cases of initial treatment and 4 cases of recurrent or refractory disease. Course of 3 to 46 months; bone marrow plasma cells in each period accounted for 19% to 54%; M protein quantitative 32.5 ~ 88.0g / L.