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利用浙江省１３个市县０～２岁儿童先心病普查发现的单纯型先心病病例，采用１∶１配比病例对照研究，调查了３５１对先心病患儿和正常对照的父母孕期前后有关暴露情况。单因素及条件Ｌｏｇｉｓｔｉｃ回归结果显示，母亲孕早期精神受刺激可能增加先心病发病危险。结果提示：为减少先心病发病危险，孕早期应合理调整自己的心理状态，保持心情愉快。
The incidence of simplex congenital heart disease (CHD) cases detected by CHD in children aged 0 ~ 2 years in 13 cities and counties in Zhejiang Province was investigated by using a 1: 1 matching case-control study. 351 pregnant women with congenital heart disease and normal controls were investigated before and after pregnancy Happening. Univariate and conditional logistic regression analysis showed that mothers’ stimulation of their mothers during the first trimester may increase the risk of congenital heart disease. The results suggest that: in order to reduce the risk of congenital heart disease, pregnancy should be reasonable to adjust their psychological state, to maintain a good mood.