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用不同锰含量的饮水(分别为2和10g/L)使孕鼠染锰,研究对子代大脑发育的影响。结果表明:(1)高剂量染锰组仔鼠大脑额叶和顶叶皮质厚度比低剂量组和对照组显著变薄,而胶质细胞纤维酸蛋白(glialfibrilaryacidprotein,GFAP)免疫反应强度及其阳性反应产物平均相对密度均明显增高;(2)高、低剂量染锰组仔鼠的扣带回皮质厚度显著较对照组增厚,GF-AP反应强度及其阳性反应产物相对密度显著升高;(3)高剂量染锰组仔鼠胼胝体的面积较对照组和低剂量组显著增大,GFAP免疫反应及其阳性反应产物相对密度明显增高,而低剂量组与对照组之间无差异。
The pregnant rats were dyed with manganese with varying levels of drinking water (2 and 10 g / L, respectively) to investigate the effects on brain development in offspring. The results showed that: (1) The thickness of frontal cortex and parietal cortex in the high dose group of manganese exposed rats was significantly thinner than that in the low dose group and the control group, while the glial fibrillary protein immunoreactivity and positive (2) The cingulate cortex thickness of the pups in high and low dose groups was significantly thicker than that in the control group, and the GF-AP reaction intensity and the relative density of the positive reaction products were significantly increased; (3) The area of corpus callosum of the pups exposed to high doses of manganese increased significantly compared with the control group and the low dose group, and the relative density of GFAP immunoreactivity and its positive reaction products was significantly increased. There was no difference between the low dose group and the control group.