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目的:观察梗阻性无精子症患者接受精道显微重建手术后应用麒麟丸后的临床疗效。方法:回顾性分析75例因梗阻性无精子症行精道重建成功者采用麒麟丸治疗后精子质量的改变情况。将75例精道重建成功的重度少精子症患者随机分为两组,即治疗组(42例)与对照组(33例),其中治疗组给予麒麟丸治疗,对照组给予安慰剂治疗。治疗3个月后,观察两组精子质量改变情况。结果:两组患者均完成了3个月的治疗。两组治疗后,精液质量均有明显提高。其中,麒麟丸组和对照组精子浓度分别从(0.57±0.25)×10~6/ml和(0.60±0.18)×10~6/ml提高到(2.83±0.59)×10~6/ml和(1.72±0.52)×10~6/ml,麒麟丸组比对照组改善更明显(P<0.05);a级精子百分率分别从(5.52±5.97)%和(5.30±6.26)%提高到(11.56±9.96)%和(10.27±6.52)%,a+b级精子百分率分别从(9.68±8.63)%和(8.64±10.10)%提高到(23.42±14.10)%和(20.81±14.70)%,正常形态精子百分率分别从(2.00±1.27)%和(2.31±0.94)%提高到(3.54±2.47)%和(3.47±1.33)%,两组治疗后精子活力和正常形态精子百分率均没有统计学差异(P>0.05)。麒麟丸组和对照组总有效率分别为88.1%和72.7%,差异亦没有统计学意义(P>0.05)。结论:对于精道重建成功的梗阻性无精子症患者,应用麒麟丸对提高精子数量有一定疗效。
Objective: To observe the clinical efficacy of Kirin Pills after obstructive azoospermia patients received microscopic reconstruction surgery. Methods: A retrospective analysis of 75 cases of obstructive azoospermia after reconstructive use of Kirin Pills after treatment of sperm quality changes. Seventy-five patients with severe oligospermia succeeded in reconstructing the trachea were randomly divided into two groups: the treatment group (42 cases) and the control group (33 cases). The treatment group received Kirin Pills and the control group received placebo. After 3 months of treatment, changes of sperm quality in both groups were observed. Results: Both groups completed 3 months of treatment. After treatment, the quality of semen were significantly improved. The sperm concentration of Kirin Pills group and control group increased from (0.57 ± 0.25) × 10 ~ 6 / ml and (0.60 ± 0.18) × 10 ~ 6 / ml to (2.83 ± 0.59) × 10 ~ 6 / ml and 1.72 ± 0.52) × 10 ~ 6 / ml, the Qilin group had a more significant improvement than the control group (P <0.05); the percentage of a-grade sperm increased from 5.52 ± 5.97% and 5.30 ± 6.26% to 11.56 ± 9.96% and 10.27 ± 6.52%, respectively. The percentage of a + b grade sperm increased from (9.68 ± 8.63)% and (8.64 ± 10.10)% to (23.42 ± 14.10)% and (20.81 ± 14.70)%, respectively The sperm percentage increased from (2.00 ± 1.27)% and (2.31 ± 0.94)% to (3.54 ± 2.47)% and (3.47 ± 1.33)%, respectively. There was no significant difference in sperm motility and normal sperm percentage after treatment P> 0.05). The total effective rates in Kirin Pills group and control group were 88.1% and 72.7% respectively, with no significant difference (P> 0.05). Conclusion: For patients with obstructive azoospermia who have been successfully reconstructed by fine tracts, the application of Kirin Pills has a certain curative effect on increasing sperm count.