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目的探讨弥漫性大B细胞淋巴瘤(DLBCL)的免疫表型特点。方法收集不同部位的DLBCL50例,通过免疫组化方法检测DLBCL的免疫表型并进行分类。结果50例CD20和CD79a均(+),13例CD45RO(+),5例CD43(+),17例CD10(+),25例bcl-6(+),28例MUM-1(+)。根据免疫表型分类,21例为生发中心B细胞样DLBCL,29例为活化B细胞样DLBCL。结论内蒙古地区DLBCL的发病部位涉及多个器官和组织,其中以颈部、扁桃体和胃肠道为多见。该地区DLBCL病例B细胞标记物CD20和CD79a均(+),部分病例T细胞标记物CD45RO(+),这可能是内蒙古地区DLBCL病例的特点。
Objective To investigate the immunophenotypic features of diffuse large B cell lymphoma (DLBCL). Methods Fifty cases of DLBCL were collected from different sites. The immunophenotype of DLBCL was detected by immunohistochemistry and classified. Results 50 cases of CD20 and CD79a (+), 13 cases of CD45RO (+), 5 cases of CD43 (+), 17 cases of CD10 (+), 25 cases of bcl-6 (+), 28 cases of MUM-1 (+). According to the immunophenotypic classification, 21 cases were germinal center B-cell-like DLBCL and 29 cases were activated B-cell-like DLBCL. Conclusion The incidence of DLBCL in Inner Mongolia involves multiple organs and tissues, of which the neck, tonsils and gastrointestinal tract are more common. In this region, both CD20 and CD79a (+) of B cell markers and CD45RO (+) of T cell markers in some cases are the features of DLBCL cases in Inner Mongolia.