【摘 要】
：
Chronic hepatitis B infection is caused by hepatitis B virus (HBV) and a total cure is yet to be achieved.The viral covalently closed circular DNA (cccDNA) is the key to establish a persistent infection within hepatocytes.Current antiviral strategies have
【机 构】
：
Sino-German Biomedical Center, Key Laboratory of Fermentation Engineering(Ministry of Education), Hu
论文部分内容阅读
Chronic hepatitis B infection is caused by hepatitis B virus (HBV) and a total cure is yet to be achieved.The viral covalently closed circular DNA (cccDNA) is the key to establish a persistent infection within hepatocytes.Current antiviral strategies have no effect on the pre-existing cccDNA reservoir.Therefore,the study of the molecular mechanism of cccDNA formation is becoming a major focus of HBV research.This review summarizes the current advances in cccDNA molecular biology and the latest studies on the elimination or inactivation of cccDNA,including three major areas:(1) epigenetic regulation of cccDNA by HBV X protein,(2) immune-mediated degradation,and (3) genome-editing nucleases.All these aspects provide clues on how to finally attain a cure for chronic hepatitis B infection.
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