论文部分内容阅读
目的：观察不同组织类型的大肠癌粘液分泌功能与浸润、转移的关系以及基底膜主要成分ＣｏｌⅣ的表达情况。方法：对４２４例大肠癌进行临床病理分析及ＩＶ型胶原免疫组化标记。结果：大肠癌组织粘液含量越高，浸润越深，淋巴结及远处转移率越高；粘液含量与癌组织分化程度关系不大；癌组织中ＣｏｌⅣ普遍缺失，粘液含量越高，ＣｏｌⅣ缺失越明显。结论：大肠癌粘液分泌功能分化与侵袭、转移能力呈正相关，这种能力可能与ＣｏｌⅣ等基底膜物质的缺失有关
Objective: To observe the relationship between mucocrine secretion and invasion and metastasis of colorectal cancer in different tissue types and the expression of ColIV, the main component of the basement membrane. Methods: Clinical pathological analysis and type IV collagen immunohistochemical markers were performed in 424 cases of colorectal cancer. Results: The higher the mucin content, the deeper the infiltration, the higher the lymph node metastasis rate and the distant metastasis rate; the relationship between the mucus content and the degree of differentiation of the cancer tissue was not significant; the ColIV was generally absent in the cancer tissue, and the higher the mucus content was, the more obvious the ColIV deletion was. . Conclusion: The functional differentiation of mucous secretion in colorectal cancer is positively correlated with invasion and metastasis. This ability may be related to the loss of basement membrane material such as Col IV.