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对16条犬进行射频导管消融冠状静脉窦(CS)的作用及安全性研究。射频于CS内导管电极和胸部片状电极间释放,能量为1229±711焦耳。13条犬于消融后半小时处死,3条犬于3～4周后处死。消融部位损伤长3.2±1.8mm,宽2.2±1.7mm,深2.1±1.0mm,镜下所见为边界清晰的凝固性坏死(急性期)与纤维化(慢性期)。冠状动脉、二尖瓣及心内膜均未受累。除2条犬偶发房性早搏或室性早搏外无心律失常发生,无血流动力学改变,无1例发生CS破裂。表明高能射频消融CS安全,就其损伤部位而论可能对破坏病人的左侧房室旁道有效。
Radiofrequency Catheter Ablation of Coronary Sinus (CS) in 16 Dogs and its Safety Study. RF was released between the CS inner catheter electrode and the thoracic patch electrode with an energy of 1229 ± 711 Joule. Thirteen dogs were sacrificed half an hour after ablation and three dogs were sacrificed after 3-4 weeks. The ablation site was 3.2 ± 1.8mm in length, 2.2 ± 1.7mm in width and 2.1 ± 1.0mm in depth. Microsurgical necrosis (acute phase) and fibrosis (chronic phase) were observed under the microscope. Coronary artery, mitral valve and endocardium were not involved. In addition to occasional atrial premature beats 2 or ventricular premature beats without arrhythmia, no hemodynamic changes, no case of CS rupture occurred. Show that high-energy radiofrequency ablation of CS safety, in terms of its damage may be on the destruction of the patient’s left atrioventricular bypass effective.