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目的 :探讨细胞周期依赖性激酶抑制剂 p2 7kip1与宫颈癌发生、发展、转移及预后的关系。方法 :采用免疫组织化学方法检测 86例宫颈癌、2 5例宫颈非典型增生、2 4例正常宫颈组织中p2 7kip1 表达情况。结果 :p2 7kip1 在宫颈正常组织中均呈阳性表达 ,其中强阳性率 87.5 %明显高于宫颈非典型增生或宫颈癌组织中的强阳性率 (2 8% ) (P<0 .0 1) ;宫颈癌临床 0期、 a 期～ b 期、 a～ b 期的强阳性率分别 5 2 %、2 5 %、2 1% ,0期与 期、 期之间差异有显著性 (P<0 .0 5 ) ;病理分化程度高 (G1 )、中 (G2 )、低 (G3)者的强阳性率分别为 5 2 %、2 9%、4 % ,分别比较差异均有显著性 (P<0 .0 5 ) ;有无淋巴结转移者的强阳性表达分别为 36 %、8% ,两者差异有显著性 (P<0 .0 1) ;p2 7kip1表达强阳性者 3年和 5年生存率分别为 91%和 85 % ,显著高于低表达者的 6 7%和 5 1% (P<0 .0 5 )。结论 :p2 7kip1蛋白表达的下降可能与宫颈癌发生、发展、转移有关 ,p2 7kip1可能成为反映肿瘤恶性表型的指标 ,对宫颈癌预后具有一定的参考价值。
Objective: To investigate the relationship between the cell cycle-dependent kinase inhibitor p2 7kip1 and the occurrence, development, metastasis and prognosis of cervical cancer. Methods: Immunohistochemistry was used to detect the expression of p27kip1 in 86 cases of cervical cancer, 25 cases of cervical atypical hyperplasia and 24 cases of normal cervical tissue. Results: The positive expression rate of p2 7kip1 in cervical normal tissues was 87.5%, which was significantly higher than that in cervical atypical hyperplasia or cervical carcinoma (28%) (P <0.01). The positive rates of clinical stage 0, stage a-b, and stage a-b of cervical cancer were 52%, 25%, 21% respectively. There was a significant difference between stage 0 and stage (P <0. The positive rates of G1, G2 and G3 were 52%, 29% and 4%, respectively (P <0 05) .0 5). The strong positive expression rate of lymph node metastasis was 36%, 8% respectively, there was significant difference between them (P <0.01). The 3-year and 5-year survival rate of p2 7kip1 strongly positive Were 91% and 85%, respectively, which were significantly higher than those of low expression (67% and 51%, respectively) (P <0.05). Conclusion: The decreased expression of p2 7kip1 may be related to the occurrence, development and metastasis of cervical cancer. The expression of p2 7kip1 may be an indicator of the malignant phenotype of the tumor and may be of reference value for the prognosis of cervical cancer.