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采用全细胞膜片箝技术，分别记录并比较正常对照组与慢性低氧组豚鼠单个右室心肌细胞的膜电容、L型钙电流和延迟整流钾电流峰值和电流-电压关系曲线，以探讨慢性低氧对豚鼠右室心肌细胞L型钙电流和延迟整流钾电流的影响。结果表明，上述两组细胞膜电容分别为（155±13．2）pF、（179±14，8）pF，低氧组显著大于正常对照组（P＜0．01）；L型钙电流峰值分别为（1．07±0．21）nA和（0．99±0．17）nA，两组之间无显著差异；在-20mV至＋20mV，慢性低氧组L型钙电流密度较正常对照组显著下降（P＜0．05）。在＋月mV至＋60mV之间，慢性低氧组豚鼠右室心肌细胞延迟整流钾电流幅度均小于正常对照组；在-20mV至＋60mV之间，慢性低氧组豚鼠右室心肌细胞延迟整流钾电流密度明显低于正常对照组。可见慢性低氧能使豚鼠右室心肌细胞膜电容增加，L型钙电流幅度不变，但L型钙电流密度下降；同时慢性低氧降低豚鼠右室心肌细胞延迟整流钾电流幅度和密度。
Whole-cell patch-clamp technique was used to record and compare the membrane capacitance, L-type calcium current and delayed rectifier potassium current peak and current-voltage curve of single right ventricular myocytes in normal control group and chronic hypoxia group to explore the relationship between chronic low Effects of Oxygen on L - type Calcium Current and Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes. The results showed that the membrane capacitance of the two groups were (155 ± 13.2) pF, (179 ± 14,8) pF, respectively, which were significantly higher in hypoxia group than those in normal control group (P <0.01) (1.07 ± 0.21) nA and (0.99 ± 0.17) nA, there was no significant difference between the two groups; at -20mV to +20 mV, L-type calcium current density in chronic hypoxia group than in normal control group Significantly decreased (P <0.05). Delayed rectifier potassium currents in guinea pigs with chronic hypoxia were lower than those in normal controls at + mV to + 60mV in chronic hypoxia group. Delayed rectifier potassium currents were found in guinea pigs with chronic hypoxia between -20 mV and +60 mV The density was significantly lower than the normal control group. Chronic hypoxia can increase the membrane capacitance of right ventricular myocardial cells in guinea pigs, L-type calcium current amplitude unchanged, but the L-type calcium current density decreased; while chronic hypoxia decreased guinea pig ventricular myocytes delayed rectifier potassium current amplitude and density.