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目的:观察乌拉地尔在治疗充血性心力衰竭中的疗效。方法:对40例充血性心力衰竭的患者留院治疗,在应用洋地黄、利尿剂及相关的基础病因的治疗基础上,给予乌拉地尔50 m g加入到5%葡萄糖或生理盐水500 ml中持续静脉滴注,根据患者的血压及全身症状进行调整剂量及滴速,每疗程为5~7 d。结果:心功能改善显效21例(52.5%),有效17例(42.5%),总有效率95%,无效2例(5%)。结论:乌拉地尔为α受体阻滞剂,具有扩血管作用,且具有中枢和外周双重作用,在治疗充血性心力衰竭上即可以扩张血管,降低外周血管阻力和心脏负荷,又可以防止交感神经兴奋引起的血压升高和心率加快。可以作为治疗充血性心力衰竭的较为理想的药物之一。
Objective: To observe the efficacy of Urapidil in the treatment of congestive heart failure. Methods: Forty patients with congestive heart failure were enrolled in hospital. On the basis of the treatment of digitalis, diuretics and related underlying etiology, 50 mg of urapidil was added to 500 ml of 5% dextrose or normal saline Intravenous infusion, according to the patient’s blood pressure and systemic symptoms to adjust the dose and drip rate, each course of treatment is 5 ~ 7 d. Results: There were 21 cases (52.5%) with improvement of cardiac function, 17 cases (42.5%) effective, 95% total effective and 2 cases invalid (5%). Conclusion: Urapidil is an α-blocker with vasodilator effect and dual functions of central and peripheral. It can dilate blood vessels in the treatment of congestive heart failure, reduce peripheral vascular resistance and cardiac load, and prevent sympathetic Nerve excitement caused by elevated blood pressure and heart rate. It can be used as one of the more ideal drugs for the treatment of congestive heart failure.