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本文对12例慢性活动性肝炎患者用肝脏刺激因子(HSS)治疗前后外周血单个核细胞诱生的白细胞介索—2(IL—2)的水平及IL—2受体表达的变化作了初步的探讨,并以12例健康人作对照。用H--TdR掺入法检测IL—2产生的活性,采用间接免疫荧光法检测IL—2R表达,结果表明12例慢活肝患者治疗前IL—2产生及IL—2R表达均较正常对照组明显下降(P<0.01和P<0.001);治疗后IL—2产生及IL一2R表达达正常水平(P>0.05)。治疗前后IL—2产生及IL—2R表达有显著性差异(P<0.001)。因而认为HSS对细胞免疫具有调节作用,能增强细胞免疫功能.
In this paper, the levels of interleukin-2 (IL-2) induced by peripheral blood mononuclear cells and the changes of IL-2 receptor expression in 12 chronic active hepatitis patients before and after treatment with hepatic stimulating factor (HSS) Of the discussion, and 12 healthy people as a control. The activity of IL-2 production was detected by H-TdR incorporation method. The expression of IL-2R was detected by indirect immunofluorescence assay. The results showed that IL-2 production and IL-2R expression in 12 patients with chronic liver disease were significantly lower than those in normal control (P <0.01 and P <0.001). IL-2 production and IL-2R expression reached the normal level after treatment (P> 0.05). Before and after treatment IL-2 production and IL-2R expression was significantly different (P <0.001). So that HSS has a regulatory role in cellular immunity, can enhance cellular immune function.