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应用胶质银染色技术，对４５例不同分化程度的膀胱移行细胞癌，及１０例膀胱粘膜上皮进行核仁组成区相关嗜银蛋白（ＡｇＮＯＲ）定量观察。结果表明：各级移行细胞癌细胞核内ＡｇＮＯＲ颗粒数及ＡｇＮＯＲ异形率均有显著性差异，膀胱粘膜与Ⅰ级移行细胞癌上述指标亦有显著差异（Ｐ＜０．０５）。提示：ＡｇＮＯＲ定量对判断膀胱移行细胞癌分化程度及肿瘤分级有一定帮助，且与ＰＣＮＡ定量有良好的相关性，均可作为研究膀胱肿瘤生物学行为的良好指标。
Using colloidal silver staining technique, 45 cases of differentiating bladder transitional cell carcinoma and 10 cases of bladder mucosal epithelium were subjected to quantification of AgNOR. The results showed that there were significant differences in the number of AgNOR particles and AgNOR profile in transitional cell carcinoma cells at different levels, and there were also significant differences in the above indicators between bladder mucosa and grade I transitional cell carcinoma (P<0.05). Tip: AgNOR quantification is helpful for judging the differentiation and tumor grade of transitional cell carcinoma of the bladder, and has good correlation with PCNA quantification, and can be used as a good indicator to study the biological behavior of bladder cancer.