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直接经皮冠状动脉介入术是恢复急性ST段抬高型心肌梗死患者梗死相关动脉血流最有效的手段之一;但是,由于存在高血栓负荷及远端栓塞等因素,心外膜冠状动脉通畅并不等于实现了正常的心肌灌注.早期研究显示直接经皮冠状动脉介入术时应用血栓抽吸有助于改善临床预后.然而,新近研究得出不同的结论.现对血栓抽吸在直接经皮冠状动脉介入术中的应用进展进行综述.“,”Primary percutaneous coronary intervention is one of the most effective treatments to restore blood flow of infarct-related artery in patients with acute ST segment elevation myocardial infarction.However,restoration of epicardial coronary artery patency does not equate with normal myocardial reperfution,mainly due to high thrombus burden and distal embolization of the thrombus.Early evidence for manual thrombus aspiration was beneficial to reduce the distal embolization.However,the evidence from recent trials did not support the routine use of manual thrombus aspiration in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention.In this paper,the research progress of application of thrombus aspiration were reviewed.