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头颈部小的局限性鳞癌用手术或放疗五年生存70～90％,然晚期可切除者则为10～60％。尽管用最佳的局部治疗(手术和放疗),而局部或区域性复发高达50％,远处转移10～30％。为减少功能和美容上的损害,并降低局部和远处转移,作者从1978～1982年对462例可切除的Ⅲ或Ⅳ期口腔、喉及下咽癌以三种方法作前瞻性研究比较:(1)手术+放疗;(2)化疗+手术+放疗;(3)化疗+手术+放疗+维持化疗。化疗为顺铂100mg/m~2,在第一天作30分钟静脉输入,第三天以博莱霉索15mg/m~2作静脉弹丸注入,然后于3～7天以博莱霉素15mg/m~2/d连续输入。给顺铂时要伴水化及甘露醇利尿。于18～21天中评定化疗效果。在诱导化疗后七天内作手术。术后第三或第四周开
The limited squamous cell carcinoma of the head and neck with surgery or radiotherapy survival of 70 to 90% for five years, but the late resection is 10 to 60%. Despite the best local treatment (surgery and radiotherapy), local or regional recurrence of up to 50%, distant transfer of 10 to 30%. In order to reduce functional and cosmetic damage and reduce local and distant metastases, the authors performed a prospective study comparing 462 resectable stage III, IV or laryngeal, hypopharyngeal and hypopharyngeal cancers from 1978 to 1982 using three methods: (1) surgery + radiotherapy; (2) chemotherapy + surgery + radiotherapy; (3) chemotherapy + surgery + radiotherapy + maintenance chemotherapy. Chemotherapy was cisplatin 100 mg/m 2 , 30 minutes intravenous infusion on the first day, and 15 mg/m 2 intravenous injection of bolusemycin on the third day, followed by bleomycin 15 mg on days 3-7. /m~2/d Continuous input. When cisplatin is accompanied by hydration and urinary diuresis. The effect of chemotherapy was evaluated in 18 to 21 days. Surgery was performed within seven days after induction chemotherapy. Third or fourth week after surgery