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目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血凝参数变化在临床中的意义。方法选择OSAHS患者64例及健康对照组54例,采用血凝仪检测患者及正常对照组静脉血凝血酶原时间(PT)、部分凝血活酶时间(APTT)、血浆纤维蛋白原(FIB)、凝血酶时间(TT)、血浆抗凝血酶III(A-TIII)。结果OSAHS患者与正常人相比,PT、APTT、TT缩短,血浆FIB增加,血浆A-TIII活性降低(P<0.05)。结论OSAHS患者存在凝血、抗凝、纤溶状态变化,可能是OSAHS患者易合并心脑血管栓塞性疾病的重要原因。
Objective To investigate the clinical significance of changes of hemagglutination parameters in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods Sixty-four patients with OSAHS and 54 healthy controls were enrolled in this study. Venous thromboplastin time (PT), partial thromboplastin time (APTT), fibrinogen (FIB) Thrombin time (TT), plasma antithrombin III (A-TIII). Results In OSAHS patients, PT, APTT, TT were shortened, plasma FIB was increased and plasma A-TIII activity was decreased (P <0.05). Conclusion The coagulation, anticoagulation and fibrinolysis in patients with OSAHS may be an important reason for OSAHS complicated with cardiovascular and cerebrovascular embolism.