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目的:探讨窒息新生儿血小板参数及脑血流动力学变化的关系及临床意义。方法:选取轻度窒息新生儿28例和重度窒息新生儿19例,分别应用全自动血细胞分析仪和经颅多普勒超声动态检测新生儿的血小板参数、大脑中动脉的血流动力学参数,分别按窒息程度进行比较。结果:重度与轻度窒息新生儿血小板(PLT)显著降低,血小板平均体积(MPV)与血小板体积分布宽度(PDW)明显增高,与轻度窒息新生儿比较,差异有统计学意义(P<0.05)。重度窒息新生儿发生显著的脑血流动力学改变,血流速度减慢,阻力指数(RI)增加,与轻度窒息新生儿比较,差异有统计学意义(P<0.05)。结论:血小板参数及脑血流动力学的变化对窒息后脑损伤的诊断及病情评估具有指导意义。
Objective: To investigate the relationship between platelet parameters and cerebral hemodynamics in neonates with asphyxia and its clinical significance. Methods: Twenty-eight neonates with mild asphyxia and 19 neonates with severe asphyxia were selected. Platelet parameters, hemodynamics parameters of middle cerebral artery were detected by automatic hematology analyzer and transcranial Doppler echocardiography. Respectively, according to the degree of asphyxia. Results: PLT, MPV and PDW were significantly higher in neonates with severe and mild asphyxia than those in mild asphyxia (P <0.05) ). Severe asphyxia in neonates significant cerebral hemodynamic changes, blood flow slowed down, resistance index (RI) increased, compared with mild asphyxia neonates, the difference was statistically significant (P <0.05). Conclusion: The changes of platelet parameters and cerebral hemodynamics are instructive in the diagnosis and assessment of brain injury after asphyxia.