background To investigate the effect of intra-aortic balloon pumping (IABP) on no-reflow phenomenon in primary percutaneous coronary intervention (PCI) for ST-Elevation Myocardial Infarction (STEMI). Methods Clinical data of 22 acute myocardial infarction patients after PCI with angiographic no-reflow phenomenon were retrospectively analyzed between January 2006 and December 2009.12 patients underwent IABP, other 10 patients as control group. We observed difference of cardiac structure, brain natriuretic peptide (BNP) and ventricular systolic function between two group, as well as cardiac injury markers (MYO,CK-MB, cTnI) in both groups on the days of 1, 2, 3, 5, 7, 10 after the different interventions. In addition, cardiac structure and ventricular systolic function including left atrium medial diameter (LAMD), left ventricular medial diameter (LVMD), left ventricular ejection fraction (LVEF) was evaluated after 10 days, 3 months,6 months. Finally, statistics was used to analysis the data. Results The several vasoactive substances as well as cardiac injury markers and LAMD, LVMD, LVEF of 10 days, 3 months, 6 months of IABP group were significant difference with control group (P < 0.05). BNP targets of IABP group compared with the control group no significant difference (P > 0.05). Conclusions IABP has effects on prognosis in STEMI patients who performed PCI with angiographic no-reflow phenomenon, which is conducive to recovery of heart function. background To investigate the effect of intra-aortic balloon pumping (IABP) on no-reflow phenomenon in primary percutaneous coronary intervention (PCI) for ST-Elevation Myocardial Infarction (STEMI). Methods Clinical data of 22 acute myocardial infarction patients after PCI with angiographic no-reflow phenomenon were retrospectively analyzed between January 2006 and December 2009.12 patients underwent IABP, other 10 patients as control group. We observed difference of cardiac structure, brain natriuretic peptide (BNP) and ventricular systolic function between two groups, as well as cardiac injury (MYO, CK-MB, cTnI) in both groups on the days of 1, 2, 3, 5, 7, 10 after the different interventions. In addition, cardiac structure and ventricular systolic function including left atrium medial diameter (LAMD) , left ventricular medial diameter (LVMD), left ventricular ejection fraction (LVEF) was evaluated after 10 days, 3 months, 6 months. Finally, statistics was used to analyze the d ata. Results The several vasoactive substances as well as cardiac injury markers and LAMD, LVMD, LVEF of 10 days, 3 months, 6 months of IABP group were significant difference with control group (P <0.05). BNP targets of IABP group compared with the control group no significant difference (P> 0.05). Conclusions IABP has effects on prognosis in STEMI patients who performed PCI with angiographic no-reflow phenomenon, which is conducive to recovery of heart function.