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目的总结胃食道返流病(GERD)相关性咳嗽的临床特征和诊疗体会,探讨GERD相关性咳嗽的发病机制。方法选择2002年1月￣2005年12月间符合慢性咳嗽诊断标准的46例患儿进行临床分析并选择性地做食道钡餐造影等一些相关检查,对拟诊为GERD相关性咳嗽的17例患儿进行抗返流治疗,并随访观察其疗效。结果本组患儿治疗后症状明显减轻或消失,随访6￣12个月,15例病情稳定,未见复发;2例因停药过早导致病情反复,再次用药后症状缓解。治疗期间未发现有何药物不良反应。结论GERD是引起慢性咳嗽的主要病因,因此,对不明原因的慢性咳嗽患儿,应常规做GER的相关检查,对临床疑诊者可给予诊断性治疗,确诊为GERD相关性咳嗽的患儿要坚持规范用药,方能取得满意疗效。
Objective To summarize the clinical features and diagnosis and treatment of GERD-related cough, and to explore the pathogenesis of GERD-related cough. Methods 46 children who met the diagnostic criteria of chronic cough between January 2002 and December 2005 were selected for clinical analysis and selective esophageal barium meal angiography and other related tests. 17 children with suspected GERD-related cough Children were anti-reflux treatment, and follow-up observation of its efficacy. Results After treatment, the symptoms of children in this group were significantly reduced or disappeared. After 6-12 months of follow-up, 15 cases were stable and no recurrence was found. Two cases were repeatedly treated with discontinuation of drug treatment and symptoms were relieved after treatment. During the treatment did not find any adverse drug reactions. Conclusions GERD is the main cause of chronic cough. Therefore, GER should be routinely diagnosed in children with unexplained chronic cough, and diagnostic tests should be given to those with clinical suspicion. Children with GERD-related cough Adhere to the standard medication in order to obtain satisfactory results.