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目的评价IL-6的两个常见基因多态性174G/C和-572G/C与胃癌风险的相关关系。方法采用病例对照研究方法,病例来源于2009年5月到2012年6月新发胃癌162例和162例对照。采用PCR-RFLP方法测定IL-6 174G/C和IL-6 572G/C基因多态性。结果研究发现以IL-6 174GG基因型作为参照,携带IL-6 174CC基因型和C等位基因能显著性的增高胃癌发病风险,调整后的OR值(95%CI)分别为2.34(1.37~4.92)和1.63(1.05~2.62)。本研究未发现携带IL-6 572G/C基因多态性能够增加胃癌发病风险。结论本研究结果表明IL-6 174G/C基因多态性可能具有促进胃癌发生和发展的作用,但IL-6 572G/C和胃癌发病风险没有相关关系。
Objective To evaluate the association between two common genetic polymorphisms of IL-6, 174G / C and -572G / C, and the risk of gastric cancer. Methods A case-control study was conducted. The cases were from 162 new-onset gastric cancer cases and 162 controls in May 2009 to June 2012. The polymorphisms of IL-6 174G / C and IL-6 572G / C were determined by PCR-RFLP. Results The study found that IL-6 174GG genotype as a reference, carrying IL-6 174CC genotype and C allele can significantly increase the risk of gastric cancer, the adjusted odds ratio (95% CI) were 2.34 (1.37 ~ 4.92) and 1.63 (1.05 ~ 2.62). This study found no IL-6 572G / C polymorphism can increase the risk of gastric cancer. Conclusion The results of this study indicate that IL-6 174G / C gene polymorphism may promote the occurrence and development of gastric cancer, but IL-6 572G / C has no correlation with the risk of gastric cancer.