甲氰咪胍(Cimetidine)是1975年合成的第三代咪唑类衍生物,可选择性阻断 H_2受体,抑制所有已知胃刺激物如组织胺、五肽胃泌素等引起的胃酸分泌。是最强的胃酸分泌抑制剂之一。我国于1978年仿制并广泛应用。临床应用1.治疗十二指肠溃疡和胃溃疡:所有溃疡病人的诊断及治愈,均经胃镜证实,部分采用了双盲对照方法。国内临床评价表明:甲氰咪胍对十二指肠溃疡的治愈率平均为70.5%;对胃溃疡的治愈率平均为78.7%。消化性溃疡治愈后复发率较高,国 Cimetidine is a third-generation imidazole derivative synthesized in 1975, which selectively blocks H 2 receptors and inhibits gastric acid secretion caused by all known gastric stimuli such as histamine and pentagastrin . Is one of the strongest gastric acid secretion inhibitors. My country imitated in 1978 and widely used. Clinical application 1. The treatment of duodenal ulcer and gastric ulcer: All ulcers in patients with diagnosis and cure were confirmed by gastroscopy, in part by a double-blind control method. Clinical evaluation shows that: cimetidine cure rate of duodenal ulcer averaged 70.5%; the cure rate of gastric ulcer averaged 78.7%. Peptic ulcer recurrence rate after treatment is higher, the country