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目的:观察泛福舒对慢性阻塞性肺疾病急性发作的预防作用。方法:慢性阻塞性肺疾病患者60例随机分为2组,每组30例。对照组给予吸氧、解痉、平喘、抗感染(必要时)等常规治疗,治疗组在对照组治疗基础上给予泛福舒7 mg空腹口服,1次/d,每月连用10 d,连用3个月。随访6个月,观察慢性阻塞性肺疾病急性发作次数,发作天数,抗生素应用时间,6 min步行距离及用药后90 d免疫指标并进行比较。结果:治疗组慢性阻塞性肺疾病急性发作次数、发作天数、抗生素应用时间均较对照组缩短(P<0.05),6 min步行距离较对照组延长(P<0.05),免疫球蛋白IgG,IgA较对照组升高(P<0.05),补体C3下降(P<0.05)。结论:泛福舒预防慢性阻塞性肺疾病急性发作安全有效。
Objective: To observe the preventive effect of Pan Fu Shu on the acute attack of chronic obstructive pulmonary disease. Methods: Sixty patients with chronic obstructive pulmonary disease were randomly divided into two groups (30 in each group). The patients in the control group were given conventional therapy such as oxygen inhalation, antispasmodic, antiasthmatic and anti-infective (if necessary). The patients in the treatment group were given Pan Fu Shu 7 mg fasting orally on the basis of the control group once a day for 10 days, Used in conjunction for 3 months. The patients were followed up for 6 months. The number of acute exacerbations, the number of seizure days, antibiotic application time, 6-minute walk distance and 90-day immune indexes were observed and compared. Results: The number of acute exacerbations, the number of seizure days and the antibiotic application time in the treatment group were shorter than those in the control group (P <0.05), and the walking distance at 6 min was longer than that in the control group (P <0.05). Immunoglobulin IgG, IgA Compared with the control group (P <0.05), complement C3 decreased (P <0.05). Conclusion: Pan Fu Shu in the prevention of acute exacerbation of chronic obstructive pulmonary disease is safe and effective.