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目的 探讨甲状腺肿瘤组织中雌激素受体 (ER)、孕激素受体 (PR)的表达与肿瘤浸润转移的关系。方法 应用SABC免疫组化法 ,对 10 0例甲状腺癌及 2 8例甲状腺良性肿瘤中ER、PR进行检测。结果 甲状腺癌中ER、PR阳性表达分别为 6 7.0 %和 6 2 .0 % ,均与细胞分化程度、组织学类型有关 ,但其阳性表达与年龄、性别无关。ER、PR在无淋巴结转移组的甲状腺癌中阳性率为 75 .4%和 70 .5 % ,显著高于有转移组的 5 3 .8%和 48.7% (P <0 .0 5 )。结论 ER、PR可作为判断肿瘤分化程度及预后的指标
Objective To investigate the relationship between the expression of estrogen receptor (ER) and progesterone receptor (PR) and the invasion and metastasis of tumor in thyroid tumors. Methods ER and PR in 100 cases of thyroid cancer and 28 cases of benign thyroid tumors were detected by SABC immunohistochemistry. Results The positive expressions of ER and PR in thyroid carcinoma were 67.0 % and 62.0% respectively, which were related to the degree of cell differentiation and histological type, but the positive expression of ER and PR was not related to age or sex. The positive rate of ER and PR in thyroid cancer without lymph node metastasis was 75.4% and 70.5%, which was significantly higher than that in the metastatic group (53.8% and 48.7%, respectively) (P < 0.05). Conclusion ER and PR can be used as indicators to judge the degree of tumor differentiation and prognosis