血液粘稠度增加综合征(Hyperviscositysyndrome)是指血液粘稠度显著增加而引起血液流体力学抵抗增加所出现的一系列特有的临床症状,血液粘稠度增加见于:红细胞显著增加,如真性红细胞增加症;血流中红细胞不易变形,如镰状红细胞症;及血浆蛋白显著增加,如巨球蛋白血症等等。其中,尤以血浆蛋白显著增加时易于发生本综合征。血浆蛋白增加疾病的本综合征发生率:原发性巨球蛋白血症最为多见,一般为40%。IgG型骨髓瘤为4%左右,IgA型骨髓瘤少见。此外,可常见于免疫球蛋白复合体形成者。巨球蛋白血症IgM> Hyperviscosity Syndrome refers to a series of unique clinical symptoms that arise from a significant increase in blood viscosity resulting in increased hemodynamic resistance. Increased blood viscosity is found in a marked increase in red blood cells, such as an increase in true red blood cells Symptoms; red blood cells in the blood flow is not easy to deform, such as sickle cell disease; and plasma protein increased significantly, such as macroglobulinemia and so on. Among them, especially in the plasma protein is significantly increased prone to the syndrome. Plasma protein increased incidence of the syndrome of the disease: the most common primary macroglobulinemia, usually 40%. IgG-type myeloma is about 4%, rare IgA-type myeloma. In addition, it can be common in immunoglobulin complex formation. Macroglobulinemia IgM>