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目的:检测Duraphat varnish涂布于乳牙后,其釉质内氟元素含量的变化,为临床使用Duraphat varnish预防乳牙龋病提供实验依据。方法:利用电子探针,检测乳牙釉质涂布Duraphat varnish后不同深度的氟含量,并与氟化钠涂布组和生理盐水对照组进行比较;使用X射线光电子能谱仪研究Duraphat varnish涂布剂量及周期变化对乳牙釉质内氟含量的影响。采用SPSS17.0软件包对数据进行统计学分析。结果:对照组、氟化钠组及Duraphat varnish组的氟元素重量百分含量均值分别为(0.0406±0.0234)wt%、(0.1006±0.1040)wt%和(0.1844±0.1293)wt%,Duraphat varnish组氟含量高于氟化钠组,有显著性差异(P<0.01)。Duraphat varnish涂布周期与氟含量关系的实验中,短周期组及长周期组釉质表层下10μm处氟元素重量百分含量均值分别为(0.2407±0.0034)wt%、(0.1434±0.0133)wt%,短周期组氟含量高于长周期组,有显著性差异(P<0.01)。在涂布剂量与氟含量关系的实验中,低剂量组与高剂量组釉质表层下10μm处氟元素重量百分含量均值分别为(0.4417±0.0034)wt%、(0.4413±0.0044)wt%,低剂量组与高剂量组氟含量差别无统计学意义(P>0.05)。结论:乳牙釉质表面局部涂布Duraphat varnish后,釉质中的氟浓度明显升高。缩短该制剂的涂布周期,能有效增加釉质表层内的氟含量,但釉质内氟含量并不随Duraphat varnish涂布剂量增加而升高。
OBJECTIVE: To detect the change of fluoride content in enamel after Duraphat varnish was applied to deciduous teeth, and to provide experimental evidence for clinical use of Duraphat varnish to prevent deciduous teeth dental caries. Methods: The fluorine content of Duraphat varnish at different depths after enamel coating was detected by electron probe and compared with sodium fluoride-coated group and saline control group. X-ray photoelectron spectroscopy was used to study the effect of Duraphat varnish coating dose Effect of periodic changes on fluoride content in primary enamel. SPSS17.0 software package for statistical analysis of the data. Results: The average fluoride content in the control group, sodium fluoride group and Duraphat varnish group were (0.0406 ± 0.0234) wt%, (0.1006 ± 0.1040) wt% and (0.1844 ± 0.1293) wt%, respectively. Duraphat varnish group Fluorine content was higher than sodium fluoride group, there was a significant difference (P <0.01). Duraphat varnish coating period and fluorine content in the experiment, the short-period group and the long-period group enamel surface 10μm under the fluoride content of the average weight were (0.2407 ± 0.0034) wt%, (0.1434 ± 0.0133) wt% The content of fluoride in the short-term group was higher than that in the long-term group (P <0.01). In the experiment of the relation between the dose and the fluorine content, the average content of fluorine in the lower 10μm and the lower 10μm enamel surface were (0.4417 ± 0.0034) wt%, (0.4413 ± 0.0044) wt% and There was no significant difference in fluoride content between dose group and high dose group (P> 0.05). Conclusion: After the local application of Duraphat varnish on the surface of enamel, the fluoride concentration in the enamel is obviously increased. Shorten the coating cycle of the preparation, can effectively increase the fluoride content in the enamel surface, but the enamel fluoride content does not increase with Duraphat varnish coating dose increases.