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继发性甲状旁腺功能亢进症 (SHPT)是慢性肾功能衰竭 (CRF)及终末期肾病 (ESRD)患者常见的并发症之一 ,并随原发病进展而逐渐加重 ,而且甲状旁腺激素 (PTH)是肾病进展的指标之一。作者从PTH的生理意义、在CRF或ESRD时PTH升高的原因及其临床意义、临床测定PTH浓度的方法、PTH升高与基因 (CYP2D6、GSTT1及GSTM1 )多态性的关系等方面 ,具体阐述了PTH测定的临床意义
Secondary hyperparathyroidism (SHPT) is one of the common complications in patients with chronic renal failure (CRF) and end-stage renal disease (ESRD), and gradually aggravates with the progression of primary disease. And parathyroid hormone (PTH) is one of the indicators of nephropathy. The reason of the physiological significance of PTH, the reason of PTH rising in CRF or ESRD and its clinical significance, the method of clinical determination of PTH concentration, the relationship between the increase of PTH and the polymorphism of genes (CYP2D6, GSTT1 and GSTM1), etc. Described the clinical significance of PTH determination