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目的：比较乙基叔丁醚（ＥＴＢＥ）和甲基叔丁醚（ＭＴＢＥ）的溶石作用与毒副反应。方法：分别将ＭＴＢＥ、ＥＴＢＥ和生理盐水放入含等量胆石的试管（体外试验），和将三种试剂等量滴注入含有胆石的兔模型（体内试验），一定时间后检测结石减重率、观察兔肝病理变化，以及将两种试剂滴眼，观察球结膜反应。结果：体内外试验胆石减重率，ＭＴＢＥ与ＥＴＢＥ相似。球结膜刺激反应，ＥＴＢＥ在２８小时而ＭＴＢＥ在１０２小时后消退；兔模型肝脏病理变化，ＥＴＢＥ组较轻、ＭＴＢＥ组重。结论：ＥＴＢＥ溶石作用与ＭＴＢＥ相近，毒副作用前者明显低于后者。
OBJECTIVE: To compare the dissolution effect and toxic side effects of ethyl tert-butyl ether (ETBE) and methyl tert-butyl ether (MTBE). Methods: MTBE, ETBE and normal saline were placed in tubes containing the same amount of gallstone (in vitro test), and the same amount of three reagents were injected into the gallstone-containing rabbit model (in vivo test). After a certain period of time, Rate, observe the pathological changes of rabbit liver, and the two kinds of reagents eye drops, observe the conjunctival reaction. Results: The gallstone weight loss rate was tested in vitro and in vivo with similar MTBE and ETBE. Conjunctival irritation reaction, ETBE at 28 hours and MTBE subside after 102 hours; rabbit liver pathological changes, ETBE group lighter, MTBE group weight. Conclusion: The effect of ETBE is similar to that of MTBE, and the former is lower than the latter.