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肾移植术后患者要长期服用免疫抑制剂预防或治疗移植物排斥反应,环孢素(CsA)是器官移植受者普遍应用的免疫抑制药之一。肾移植术后患者服用CsA达稳态后,服药剂量不变的情况下,其CsA的血药浓度应当差别很小,但实际监测中发现患者CsA的血药浓度与预期结果相差较大。
Long-term use of immunosuppressive agents in patients after renal transplantation to prevent or treat graft rejection, cyclosporine (CsA) is one of the commonly used immunosuppressive drugs in organ transplant recipients. CsA in renal transplantation patients after taking steady-state, taking the same dose, the plasma concentration of CsA should be very small, but the actual monitoring found that patients with CsA plasma concentration and the expected difference between the results.