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【目的】探讨血清胆固醇水平(CHOL)在妊娠合并重型肝炎预后判断中的临床意义。【方法】收集40例在我院治疗的妊娠合并重型肝炎患者的临床资料,按其预后分为存活组(22例)及死亡组(18例),回顾性分析CHOL与病情变化及预后的关系。【结果】妊娠合并重型肝炎存活组与死亡组的CHOL差异有统计学意义。CHOL≤1.6mmol/L、CHOL进行性下降或凝血酶原活动度(PTA)≤30%的同时CHOL≤2.0mmol/L,病死率高。CHOL与PTA间存在正相关(r=0.369)。【结论】CHOL可作为妊娠合并重型肝炎预后判断的临床联合指标之一,CHOL≤1.6mmol/L、CHOL进行性下降、PTA≤30%的同时CHOL≤2.0mmol/L,均提示预后不良。
【Objective】 To investigate the clinical significance of serum cholesterol level (CHOL) in predicting the prognosis of severe hepatitis in pregnancy. 【Methods】 The clinical data of 40 pregnant women with severe hepatitis treated in our hospital were collected. According to their prognosis, they were divided into survival group (n = 22) and death group (n = 18). The relationship between CHOL and prognosis was retrospectively analyzed . 【Results】 There were significant differences in CHOL between pregnant women with severe hepatitis and those with death. CHOL ≤ 1.6mmol / L, CHOL progressive decline or prothrombin activity (PTA) ≤ 30% while CHOL ≤ 2.0mmol / L, high mortality. There was a positive correlation between CHOL and PTA (r = 0.369). 【Conclusion】 CHOL can be used as one of the clinical indexes for predicting the prognosis of severe hepatitis in pregnancy. CHOL≤1.6mmol / L, CHOL progressively decreased, PTA≤30% and CHOL≤2.0mmol / L, all imply that the prognosis is poor.