论文部分内容阅读
目的探讨CEA、CA19-9、CA72-4单项检测与联合检测在消化道肿瘤诊断中的价值。方法采用电化学发光法检测225例胃癌患者、180例结直肠癌患者、40例食管癌患者(以上为恶性消化道肿瘤组)、72例良性消化道疾病患者(良性消化道疾病组)、214名健康者(对照组)血清中CEA、CA19-9和CA72-4水平。结果恶性消化道肿瘤患者血清CEA、CA19-9、CA72-4的阳性检测率明显高于良性消化道疾病组,而良性消化道疾病组又明显高于对照组,差异有显著性(P<0.01)。三者联合检测灵敏度、特异性、准确性均显著提高(P<0.05)。结论血清CEA、CA19-9、CA72-4联检对消化系统肿瘤的诊断及与消化系统良性肿瘤的鉴别诊断具有重要的价值,为早期诊断及早期治疗提供有力的依据。
Objective To investigate the value of single detection and combined detection of CEA, CA19-9 and CA72-4 in the diagnosis of gastrointestinal tumors. Methods Electrochemiluminescence was used to detect 225 cases of gastric cancer, 180 cases of colorectal cancer, 40 cases of esophageal cancer (above malignant digestive tract tumor group), 72 cases of benign digestive tract disease (benign gastrointestinal disease group), 214 Serum CEA, CA19-9 and CA72-4 levels in healthy controls (control group). Results The positive rates of serum CEA, CA19-9 and CA72-4 in patients with malignant gastrointestinal tumors were significantly higher than those in benign gastrointestinal diseases, but were significantly higher in patients with benign digestive diseases than in controls (P <0.01) ). The sensitivity, specificity and accuracy of the combined detection were significantly increased (P <0.05). Conclusion The combination of serum CEA, CA19-9 and CA72-4 has important value in the diagnosis of digestive system tumors and in the differential diagnosis of benign tumors of digestive system, providing a strong basis for early diagnosis and early treatment.