川崎病(KD)是一种原因不明的伴弥漫性血管炎的急性炎症性疾病,常伴有多种血液异常,包括血小板活化,中性粒细胞介导的活性氧产生增加,花生四烯酸代谢改变,这些改变在 KD 病理变化中起重要作用。血栓素烷(TXA_2)和前列环素(PGI_2)均系细胞膜内花生四烯酸经环氧化酶等作用转化而来。在血小板,它转化为 TXA_2并很快代谢为 TXB_2,是一种强力的促凝剂和血管收缩剂;在血管壁,它转化为 PGI_2并很 Kawasaki disease (KD) is an unexplained acute inflammatory disease with diffuse vasculitis, often accompanied by a variety of blood abnormalities including platelet activation, increased neutrophil-mediated reactive oxygen species production, increased arachidonic acid Metabolic changes, these changes play an important role in the pathological changes of KD. Thromboxane (TXA_2) and prostacyclin (PGI_2) are the membrane of arachidonic acid by the role of cyclooxygenase and other transformation. In platelets, it is converted to TXA_2 and is rapidly metabolized to TXB_2, which is a potent coagulant and vasoconstrictor; it is converted to PGI_2 in the vascular wall